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pentobarbital will lessen the extent or outcome of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Robust CYP3A4 inducers might lower midostaurin concentrations leading to lessened efficacy.pentobarbital will reduce the extent or outcome of alosetron by affecting hepatic/intestinal enzyme CYP3A4